Rabu, 26 Mei 2021

Combining AstraZeneca and Pfizer vaccines may boost your immunity to Covid -

Preliminary studies suggest mixing AstraZeneca and Pfizer vaccines is likely to boost immunity to Covid-19, although experts say no one should be holding out for a hybrid inoculation.

A Spanish study has revealed an increased immunity when a Pfizer inoculation followed an AstraZeneca jab, although the experiment was only a small sample.

The peer-reviewed medical journal The Lancet also published findings, from an Oxford and Nottingham University study, involving more than 460 participants, that showed an increase in immunity when a Pfizer inoculation followed an AstraZeneca jab.

Spain’s Carlos Health Institute tested people under 60 years of age who received the Comirnaty vaccine (BioNtech/Pfizer) after already having received a first and only dose of Vaxzevria (AstraZeneca).

There were at least eight weeks between doses and 441 participants who received a second dose.

“The response of the immune system is greatly enhanced after the second dose of the Comirnaty vaccine, while the observed adverse effects are within what is expected, are mild or moderate and are mostly restricted to the first 2-3 days after receiving the vaccine,” the report stated.

“In no case has a hospital admission secondary to the use of this vaccination regimen been reported within this clinical trial.”

The recently published Lancet paper showed that “in this interim safety analysis, we found an increase in systemic reactogenicity after the boost dose reported by participants in heterologous vaccine schedules”.

Peter Collignon, from the Australian National University Medical School, said the jury may still be out on whether mixing doses would enhance immunity, but The Lancet paper was positive.

“It does suggest you can mix vaccines,” Professor Collignon said.

“You seem to have more ‘reactions’ that are short-lived but have a better immune response as well. That likely gives you more protection, but we need real-life data to be sure of that rather than just lab-based antibody data.”

Griffith University infectious disease researcher Johnson Mak said the studies were pointing in the right direction and getting two different vaccines may be more beneficial than just one.

However, he advised against anyone holding off getting AstraZeneca and waiting for Pfizer.

“Mixed vaccination strategies are being further evaluated in a real-world setting, but signs are good,” Professor Mak said.

“I suspect those who received mixed vaccines might be better off (having stronger immune response) at the end.

“The blood clot cases of AstraZeneca vaccine cases are extremely low, which can readily be handled by Australian healthcare system, and I would encourage everyone to get their vaccination as quickly as possible regardless which form is available to them.”

Victoria’s chief health officer Brett Sutton said the AstraZeneca vaccine provided “extremely good protection” against serious illness and anyone needing hospital treatment.

He would not recommend anyone mixing and matching the inoculations.

“It is just worthwhile to get that vaccine. It should be followed up on current recommendations – 12 weeks later with the second dose,” he told the media on Wednesday.

“The mixing and matching a matter for someone else, but there is no reason to believe you cannot get a follow-up dose with AstraZeneca that does not work.”

Receiving either AstraZeneca or Pfizer vaccines would be enough to stave off serious illness, and there was no desperate need for anyone to receive a hybrid of the two vaccines, Professor Collignon said.

“If you look at English and Scottish data, from a personal protection point of view, getting either Pfizer or AstraZeneca, they are protective against severe disease, against the initial variant and the UK variant,” he said.

“All the data we have at the moment, and it’s in large numbers and mainly from England, both are equally efficacious.”


Pfizer(aka: Comirnaty / BNT162b2):

Developed by Pfizer and BioNTech.

It is an mRNA (mRNA teach cells to make protein) vaccine.

It contains the genetic code for an important part of the virus, called the ‘spike protein’.

After getting the injection, your body reads the genetic code and makes copies of the spike protein.

Your immune system then detects these spike proteins and learns how to recognise and fight against Covid-19.

The genetic code is quickly broken down and cleared away by the body.


Developed by The University of Oxford and AstraZeneca.

It contains the genetic code for an important part of the virus, called the spike protein.

The code is carried into your cells by a harmless common cold “carrier”virus (an adenovirus).

Your body then makes and uses the spike protein to learn to recognise and fight against SARS-CoV-2.

The carrier adenovirus has been modified so that it cannot spread to other cells and cause infection. For this reason, COVID-19 vaccine AstraZeneca does not behave like a “live vaccine”.

NB: No vaccine supplied in the world contains live coronavirus.

• Source: National Centre for Immunisation Research

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2021-05-26 04:49:48Z

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